Endocrine Abstracts

Children and young people (CYP) with Type 1 Diabetes who maintain a healthy BMI, diet and accurate carbohydrate-counting have lower risk of cardiovascular disease and diabetes complications. The tracking of key Diabetes health checks and outcomes via the National Paediatric Diabetes Audit (NPDA) has been successful in ensuring year-on-year improvement of national average HbA1c. Aside from BMI however, Dietetic-specific outcomes are not currently included in the NPDA. Therefore...

Background: Metabolic endotoxaemia (raised bacterial endotoxin in serum after high-fat feeding) has been shown to reduce insulin sensitivity in humans through systemic inflammation and oxidative stress. Mitochondria represent the main source of cellular reactive oxygen species and mutations in mitochondrial DNA often result in a diabetic phenotype. However, the direct cellular impact of endotoxin on mitochondrial respiration and DNA integrity, particularly within the context o...

Background: The pathogenesis of obesity and T2DM mediates mitochondrial dysfunction which, in part, may arise as a consequence of endoplasmic reticulum (ER) stress. However, the potential impact of ER stress on mitochondria dysfunction is unclear. Therefore, we investigated whether induction of ER stress contributes to mitochondrial dysfunction in human adipocytes using 1) human differentiated adipocyte cell line (Chub-S7, n=12); and 2) primary differentiated lean and...